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Lightsource bp is a global solar leader and 50:50 JV partner with bp, working with utilities, businesses, local communities and governments to help meet the rising demand for affordable, reliable and sustainable energy.
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Lightsource bp is a global leader with local impact. We continue to grow teams, partnerships and projects throughout the world. Every region receives a tailored approach and is managed by a local team. Visit one of our regional websites to find out more about our local projects, initiatives and key contacts.
Find out more about how Lightsource bp works and operates and our partnership with bp. As a business we care deeply about the impact of our projects, our culture and values, and our team members. We believe that sustainability and social responsibility are crucial for long-term business success and this is embedded within our business model, holding us accountable to those principles.
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(Left) Close up photograph of the SBH connector system with titanium cannula integrated with a one-way silicone valve, conical titanium coil assembly, coring tool and delivery handle. (Right). The elliptical titanium coil is inserted by rotating into the myocardium to provide secure coupling via radial compression forces (arrows).
Fluoroscopy image of the SBH connector system with titanium conical coil embedded in LV myocardium providing a stable, hemostatically sealed platform for HeartWare HVAD in a chronic bovine model (left). Photo of the SBH system titanium connector with integrated silicone tri-leaflet valve placed in the LV apex of a human cadaver heart (right).
Summary of the implant procedure for the SBH connector system as shown in a human cadaver model. A mini-thoracotomy is performed for exposure and access to the LV apex (A). Next, the titanium coil is passed over a guidewire and inserted into the LV apex with a deployment tool (B). Once fully engaged and secured (C), the blades (D) of the integrated coring tool (E) make an incision, remove an apical core, and deliver the hemostatic one-way valve (F) resulting in the fully implanted, hemostatically-sealed SBH connector system ready for the LVAD inflow cannula (G). The entire procedure was performed without CPB and with minimal blood loss.
Summary of the implant procedure for the SBH connector system with HVAD (HeartWare, Miami Lakes FL) as shown in a bovine model. Still shot from the overhead camera during an acute HF bovine experiment showing the different surgical steps during off-pump beating heart procedure. (A) Coil is anchored at LV apex using delivery handle. (B) No tearing or bleeding was observed following anchoring of coil. (C) No significant bleeding was observed during the coring procedure. Coring motion also enables delivery of valved cannula that is pre-mounted over the coring blade. (D) Valve maintains hemostasis during exchange of coring tool and connection to the LVAD. (E) HeartWare HVAD inlet is introduced though valve with complete hemostasis. (F) HVAD is exchanged for Thoratec HeartMate II inlet cannula to show universality of system. High level of hemostasis is maintained thought the whole procedure. Complete hemostasis at 160mmHg.
Cadaver studies demonstrated the SBH connector system may be implanted via subcostal (A) or a mini-thoracotomy (B) incisions and using modified Seldinger technique. The SBH connector system also demonstrated feasibility of anatomic fit, ease of use, and hemostasis during simulated hypertension (pressures up to 170 mmHg) with clinically approved HeartMate II (C) and HVAD (D) LVAD.
The SBH connector system demonstrated stable hemostatic seal in acute the IHF bovine model as evidenced by maintenance of left ventricular peak systolic pressure (LVPpksys), LV end-diastolic pressure (LVPed), mean arterial pressure (ArtPmean), and arterial pulse pressure (ArtPpulse) post-SBH implantation and post-LVAD insertion compared to pre-SBH implant baseline.
Echocardiography images (3D iE33 Phillips Medical Systems) recorded at pre-implant baseline (A), post-implant of SBH connector system with HeartWare HVAD operating at maximum pump speed (B) and normal pump speed with animal in acute hypertension (C). Images of Thoratec HeartMate II (D) and HeartWare HVAD (E) LVAD with SBH connector system demonstrating hemostasis was maintained and LV volume unloading achieved.
The Phase I program (NIH-SBIR phase I grant 1R44HL117426-01) began on March 1, 2013 and was completed November 30, 2013. The objective of this proposal was to develop a minimally invasive surgical implant procedure and complete feasibility testing of a sutureless beating heart (SBH) connector system to facilitate LVAD implantation for the treatment of advanced HF patients. The authors thank the following individuals for their support of this feasibility study: Paul Linsky MD, Karen Lott, Laura Lott, Regina Turner, and Cary Woolard.
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